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An Analytical Solution to the Kinetics of Breakable Filament Assembly

Knowles, TPJ; Waudby, CA; Devlin, GL; Cohen, SIA; Aguzzi, A; Vendruscolo, M; Terentjev, EM; ... Dobson, CM; + view all (2009) An Analytical Solution to the Kinetics of Breakable Filament Assembly. SCIENCE , 326 (5959) 1533 - 1537. 10.1126/science.1178250.

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Abstract

We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events. Our results further reveal a range of general features of the growth kinetics of fragmenting filamentous structures, including the existence of generic scaling laws that provide mechanistic information in contexts ranging from in vitro amyloid growth to the in vivo development of mammalian prion diseases.

Type: Article
Title: An Analytical Solution to the Kinetics of Breakable Filament Assembly
DOI: 10.1126/science.1178250
Keywords: AMYLOID FIBRIL FORMATION, MECHANISM, AGGREGATION, NUCLEATION, SCRAPIE, POLYMERIZATION, PATHWAY, DISEASE, GROWTH, TIME
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/141336
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