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Plate models in chromatography: analysis and implications for scale-up

Velayudhan, AK; (1993) Plate models in chromatography: analysis and implications for scale-up. In: Tsao, GT, (ed.) Chromatography. (123 - 145). Springer Berlin Heidelberg

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Abstract

Detailed chromatographic rate theories from the literature can be used to determine the appropriate plate count for a plate model of linear chromatography so that the bandspreading generated by the detailed rate model is reproduced by the plate model. This process provides a link between the plate count and the physical parameters that cause bandspreading. Each sample component can be assigned an appropriate plate count, thus allowing the accurate simulation of multicomponent separations even for widely differing adsorbates. Analytical solutions are presented for the Craig distribution and the continuous plate model for both finite-pulse elution and frontal chromatography. The Craig model is widely considered unsuitable because it assumes discontinuous flow; it is shown that, for a suitably corrected plate count, the Craig model is as accurate as the continuous-flow plate theory (except for the case of an unretained solute). Direct calculation of effluent histories from these plate models show excellent agreement between themselves and with results from complex rate models available in the literature. Reasonable agreement is also found when the plate models are used a priori to predict experimental scale-up results. Chromatography Chromatography Look Inside Share Share this content on Facebook Share this content on Twitter Share this content on LinkedIn Other actions Export citations About this Book Reprints and Permissions

Type: Book chapter
Title: Plate models in chromatography: analysis and implications for scale-up
ISBN-13: 978-3-540-56440-9
DOI: 10.1007/BFb0046575
Publisher version: http://link.springer.com/chapter/10.1007%2FBFb0046...
Language: English
Additional information: © 1993 Springer-Verlag
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1413056
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