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Modulator Sorption in Gradient Elution Chromatography

Velayudhan, AK; (1993) Modulator Sorption in Gradient Elution Chromatography. In: Bioproducts and Bioprocesses 2. Third Conference to Promote Japan/U.S. Joint Projects and Cooperation in Biotechnology, Honolulu, Hawaii, January 6–10, 1991. (217 - 232). Springer-Verlag Berlin Heidelberg

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Abstract

Gradient elution, invented by Tiselius and his co-workers [1], employs a mobile phase whose composition at the column inlet varies with time. This is in contrast to isocratic elution, where the mobile phase composition remains constant at every point in the column throughout the separation. In fact, one of the reasons gradient elution was introduced was to hasten isocratic separations, by reducing tailing and by moving widely separated compounds closer together. It is also well-suited to the separation of macromolecules, whose retention tends to vary strongly with mobile phase composition [2], and is consequently a widely used technique in biotechnology.

Type: Book chapter
Title: Modulator Sorption in Gradient Elution Chromatography
ISBN-13: 978-3-642-49360-7
DOI: 10.1007/978-3-642-49360-7_24
Publisher version: http://link.springer.com/chapter/10.1007%2F978-3-6...
Language: English
Additional information: © 1993 Springer-Verlag Berlin Heidelberg
UCL classification: UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1413020
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