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Commercial manufacture of cell therapies

Wall, IB; Brindley, DA; (2013) Commercial manufacture of cell therapies. In: Standardisation in Cell and Tissue Engineering: Methods and Protocols. (pp. 212-239).

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Abstract

The commercial manufacture of cell-based therapies is expected to revolutionise healthcare provision over the coming decades and address growing clinical needs of an aging population and associated age-related degenerative disorders. Exciting advances in the emerging field of stem cell biology have great potential to treat many of these diseases. This chapter provides an overview of the challenges of moving from a laboratory-scale experiment to regulatorily sound industrial manufacturing platforms. The adoption of standardised protocols to attain a clearly defined, high-quality product across multiple batches is essential, as is the capacity for scale-up processing for allogeneic cell therapy or scale-out processing for autologous therapy. © 2013 Woodhead Publishing Limited. All rights reserved.

Type: Book chapter
Title: Commercial manufacture of cell therapies
ISBN-13: 9780857094193
DOI: 10.1533/9780857098726.2.212
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/1412980
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