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Quantification of cytochrome P450 reductase gene expression in human tissues.

Shephard, EA; Palmer, CN; Segall, HJ; Phillips, IR; (1992) Quantification of cytochrome P450 reductase gene expression in human tissues. Arch Biochem Biophys , 294 (1) pp. 168-172.

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Abstract

We have isolated and sequenced cDNA clones that code for a variant of human cytochrome P450 reductase. An RNase protection assay was used to quantify the corresponding mRNA in adult and fetal tissues. The results demonstrate that, in the samples analyzed, the cytochrome P450 reductase gene displays very little inter-individual variation in its expression in adult liver and is subject to little developmental or tissue-specific regulation.

Type: Article
Title: Quantification of cytochrome P450 reductase gene expression in human tissues.
Location: United States
Keywords: Aging, Amino Acid Sequence, Base Sequence, DNA, Gene Expression, Humans, Liver, Molecular Sequence Data, NADPH-Ferrihemoprotein Reductase, RNA, Messenger, Ribonucleases, Tissue Distribution
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1412701
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