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Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices

Batchelor, AM; Knopfel, T; Gasparini, F; Garthwaite, J; (1997) Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices. NEUROPHARMACOLOGY , 36 (3) 401 - 403.

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Abstract

The mGluR-mediated EPSP at parallel fibre-Purkinje cell synapses in the cerebellum was blacked concentration-dependently and reversibly by antagonists acting selectively on group-I mGluRs but not by an inhibitor of group-III receptors. The results provide pharmacological evidence that the receptor type responsible for the mGluR-EPSP is mGluR1. (C) 1997 Elsevier Science Ltd.

Type:Article
Title:Pharmacological characterization of synaptic transmission through mGluRs in rat cerebellar slices
Keywords:glutamate, metabotropic glutamate receptor, cerebellum, mGlu1 receptor, synaptic transmission, EPSP, METABOTROPIC GLUTAMATE RECEPTORS, PHENYLGLYCINE DERIVATIVES, ANTAGONISTS, SUBTYPES, ACID
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Wolfson Inst for Biomedical Research

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