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Modeling of non-linear elution chromatography for preparative-scale separations

Velayudhan, A; Ladisch, MR; Porter, JE; (1992) Modeling of non-linear elution chromatography for preparative-scale separations. AIChE Symposium Series , 88 (290) pp. 1-11.

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Abstract

Many models are available for describing elution profiles in preparative-scale overloaded chromatography. These range from empirical to theoretical and describe experimental data with varying success. This chapter reviews models and approaches to analyzing isocratic and gradient elution. When the loading is low-to-moderate in nonlinear isocratic elution, analytical solutions are available from which productivity can be calculated as a function of operating parameters. For higher loadings, optimization studies have been carried out on binary mixtures obeying Langmuirian isotherms. Gradient elution separations have been successfully scaled-up using a simplified theory.

Type: Article
Title: Modeling of non-linear elution chromatography for preparative-scale separations
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/1412234
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