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The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells

Karlsson, G; Rörby, E; Pina, C; Soneji, S; Reckzeh, K; Miharada, K; Karlsson, C; ... Enver, T; + view all (2013) The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells. Cell Reports , 4 (4) pp. 642-648. 10.1016/j.celrep.2013.07.020.

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Abstract

Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function. Using CD9 as a tool to subdivide hematopoietic stem-cell-containing populations, we provide evidence for heterogeneity at the cellular, functional, and molecular levels

Type: Article
Title: The tetraspanin CD9 affords high-purity capture of all murine hematopoietic stem cells
DOI: 10.1016/j.celrep.2013.07.020
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1411413
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