UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study

Bouillon, K; Kivimäki, M; Hamer, M; Shipley, MJ; Akbaraly, TN; Tabak, A; Singh-Manoux, A; (2013) Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study. Journal of the American Medical Directors Association , 14 (11) 851.e1-851.e6. 10.1016/j.jamda.2013.08.016. Green open access

[thumbnail of Batty_1-s2.0-S1525861013005057-main.pdf]
Preview
Text
Batty_1-s2.0-S1525861013005057-main.pdf - Published Version

Download (472kB) | Preview

Abstract

Objective: To examine whether established diabetes risk factors and diabetes risk algorithms are associated with future frailty. / Design: Prospective cohort study. Risk algorithms at baseline (1997–1999) were the Framingham Offspring, Cambridge, and Finnish diabetes risk scores. / Setting: Civil service departments in London, United Kingdom. / Participants: There were 2707 participants (72% men) aged 45 to 69 years at baseline assessment and free of diabetes. / Measurements: Risk factors (age, sex, family history of diabetes, body mass index, waist circumference, systolic and diastolic blood pressure, antihypertensive and corticosteroid treatments, history of high blood glucose, smoking status, physical activity, consumption of fruits and vegetables, fasting glucose, HDL-cholesterol, and triglycerides) were used to construct the risk algorithms. Frailty, assessed during a resurvey in 2007–2009, was denoted by the presence of 3 or more of the following indicators: self-reported exhaustion, low physical activity, slow walking speed, low grip strength, and weight loss; “prefrailty” was defined as having 2 or fewer of these indicators. / Results: After a mean follow-up of 10.5 years, 2.8% of the sample was classified as frail and 37.5% as prefrail. Increased age, being female, stopping smoking, low physical activity, and not having a daily consumption of fruits and vegetables were each associated with frailty or prefrailty. The Cambridge and Finnish diabetes risk scores were associated with frailty/prefrailty with odds ratios per 1 SD increase (disadvantage) in score of 1.18 (95% confidence interval: 1.09–1.27) and 1.27 (1.17–1.37), respectively. / Conclusion: Selected diabetes risk factors and risk scores are associated with subsequent frailty. Risk scores may have utility for frailty prediction in clinical practice.

Type: Article
Title: Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: The Whitehall II Prospective Cohort Study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jamda.2013.08.016
Publisher version: http://dx.doi.org/10.1016/j.jamda.2013.08.016
Language: English
Additional information: This is an Open Access article published under a Attribution 4.0 International (CC BY 4.0) licence (https://creativecommons.org/licenses/by/4.0/).
Keywords: Aging, frailty, diabetes risk scores, diabetes risk factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: https://discovery.ucl.ac.uk/id/eprint/1411399
Downloads since deposit
124Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item