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Crosstalk between ER stress and immunogenic cell death.

Kepp, O; Menger, L; Vacchelli, E; Locher, C; Adjemian, S; Yamazaki, T; Martins, I; ... Zitvogel, L; + view all (2013) Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev , 24 (4) pp. 311-318. 10.1016/j.cytogfr.2013.05.001.

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Abstract

Preclinical and clinical findings suggest that tumor-specific immune responses may be responsible--at least in part--for the clinical success of therapeutic regimens that rely on immunogenic cell death (ICD) inducers, including anthracyclines and oxaliplatin. The molecular pathways whereby some, but not all, cytotoxic agents promote bona fide ICD remain to be fully elucidated. Nevertheless, a central role for the endoplasmic reticulum (ER) stress response has been revealed in all scenarios of ICD described thus far. Hence, components of the ER stress machinery may constitute clinically relevant druggable targets for the induction of ICD. In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy.

Type: Article
Title: Crosstalk between ER stress and immunogenic cell death.
Location: England
DOI: 10.1016/j.cytogfr.2013.05.001
Keywords: ATP, Anthracyclines, Apoptosis, Calcium, Calreticulin, PERK, Animals, Anthracyclines, Antineoplastic Agents, Cell Death, Endoplasmic Reticulum, Endoplasmic Reticulum Stress, Humans, Mice, Neoplasms, Organoplatinum Compounds, Oxaliplatin
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1411111
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