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Serotonin in Affective Control

Dayan, P; Huys, QJM; (2009) Serotonin in Affective Control. ANNU REV NEUROSCI , 32 95 - 126. 10.1146/annurev.neuro.051508.135607.

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Abstract

Serotonin is a neuromodulator that is extensively entangled in fundamental aspects of brain function and behavior. We present a computational view of its involvement in the control of appetitively and aversively motivated actions. We first describe a range of its effects in invertebrates, endowing specific structurally fixed networks with plasticity at multiple spatial and temporal scales. We then consider its rather widespread distribution in the mammalian brain. We argue that this is associated with a more unified representational and functional role in aversive processing that is amenable to computational analyses with the kinds of reinforcement learning techniques that have helped elucidate dopamine's role in appetitive behavior. Finally, we suggest that it is only a partial reflection of dopamine because of essential asymmetries between the natural statistics of rewards and punishments.

Type:Article
Title:Serotonin in Affective Control
DOI:10.1146/annurev.neuro.051508.135607
Keywords:computational model, behavior, reward, punishment, opponency, dopamine, DORSAL RAPHE NUCLEUS, MEDIAL PREFRONTAL CORTEX, VENTRAL TEGMENTAL AREA, ACUTE TRYPTOPHAN DEPLETION, DOPAMINE NEURONS ENCODE, CENTRAL 5-HYDROXYTRYPTAMINE DEPLETION, NEMATODE CAENORHABDITIS-ELEGANS, LOBSTER STOMATOGASTRIC GANGLION, JUXTACELLULAR LABELING METHODS, 5-HT2C RECEPTOR ANTAGONIST
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Gatsby Computational Neuroscience Unit

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