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Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial.

Zajicek, J; Ball, S; Wright, D; Vickery, J; Nunn, A; Miller, D; Gomez Cano, M; ... CUPID investigator group; + view all (2013) Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. Lancet Neurology , 12 (9) 857 - 865. 10.1016/S1474-4422(13)70159-5. Green open access

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Abstract

Laboratory evidence has shown that cannabinoids might have a neuroprotective action. We investigated whether oral dronabinol (Δ(9)-tetrahydrocannabinol) might slow the course of progressive multiple sclerosis.

Type: Article
Title: Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/S1474-4422(13)70159-5
Publisher version: http://dx.doi.org/10.1016/S1474-4422(13)70159-5
Language: English
Additional information: Copyright © 2013 Elsevier Ltd All rights reserved. PMCID: PMC3744749
Keywords: Adult, Cannabinoid Receptor Agonists, Disease Progression, Double-Blind Method, Dronabinol, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Treatment Outcome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1410224
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