UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Nebulised water as a bronchoconstricting challenge in infancy.

O'Callaghan, C; Milner, AD; Webb, MS; Swarbrick, A; (1991) Nebulised water as a bronchoconstricting challenge in infancy. Arch Dis Child , 66 (8) pp. 948-951.

Full text not available from this repository.

Abstract

The pulmonary response to inhalation challenge with nebulised distilled water was measured in 100 sedated infants with a history of wheeze. Lung function was measured by total body plethysmography. Satisfactory results were obtained in 88 infants. Fifty one were considered to have responded by developing a greater than 20% decrease in specific conductance (sGaw) after nebulised water. Thirty two of these infants had previously been challenged with nebulised saline before but only one showed a greater than 20% decrease in sGaw after saline. Twenty infants who developed signs of bronchoconstriction after challenge with nebulised water were rechallenged 20 minutes later. After the initial challenge a fall in sGaw of greater than 20% was found in 19 of the 20. After a second challenge with nebulised water only 15 (75%) showed a 20% or greater decrease in sGaw. Nine of the 20 infants remained sedated and were rechallenged for a third time. Eight showed a greater than 20% decrease in sGaw. This study indicates that approximately 60% of infants with a history of wheeze will bronchoconstrict in response to inhaled nebulised water and that up to 75% show no evidence of a subsequent refractory period to inhaled water challenge.

Type: Article
Title: Nebulised water as a bronchoconstricting challenge in infancy.
Location: England
Keywords: Administration, Inhalation, Airway Resistance, Bronchial Provocation Tests, Bronchoconstriction, Humans, Infant, Lung, Plethysmography, Whole Body, Respiratory Sounds, Water
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/1409191
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item