UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes

Hughes, AD; Park, C; March, K; Coady, E; Khir, A; Chaturvedi, N; Thom, SAMG; (2013) A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes. International Journal of Cardiology , 167 (4) pp. 1329-1332. 10.1016/j.ijcard.2012.03.179.

Full text not available from this repository.

Abstract

Background/Objectives: Thiazolidinediones (TZDs), such as pioglitazone, are widely used to treat type 2 diabetes but there is evidence that their use is associated with an increased risk of heart failure. We compared the effect of pioglitazone vs placebo on left ventricular (LV) diastolic and systolic function in people with type 2 diabetes. Methods and results: 24 male or female patients with type 2 diabetes were randomized to pioglitazone (45 mg/day) or placebo in addition to current therapy for 12 weeks using a prospective double blind crossover protocol following a run-in period > 1 week and a 2 week washout period at crossover. Tissue Doppler early peak velocity (e′), a measure of LV diastolic function, was the primary outcome. Pioglitazone significantly increased e′ by 0.7(0.1, 1.3) cm/s (mean (95% confidence interval); p = 0.02) compared with placebo. Pioglitazone also increased E/A and mitral deceleration index, ejection fraction, stroke volume and weight, whereas fasting glucose, HbA1c, total peripheral resistance and LV meridional end systolic stress were decreased. Conclusions: Treatment with pioglitazone for 12 weeks improves left ventricular diastolic and systolic function in people with type 2 diabetes. © 2012 Elsevier Ireland Ltd.

Type: Article
Title: A randomized placebo controlled double blind crossover study of pioglitazone on left ventricular diastolic function in type 2 diabetes
DOI: 10.1016/j.ijcard.2012.03.179
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1407135
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item