Ebrahimkhani, MR and Mani, AR and Moore, K (2005) Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis. Gut , 54 (12) 1668 - 1671. 10.1136/gut.2004.056556.
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Abstract
Cirrhosis is associated with the development of ahyperdynamic circulation, which is secondary to thepresence of systemic vasodilatation. Several mechanismshave been postulated to be involved in the development ofsystemic vasodilatation, including increased synthesis ofnitric oxide, hyperglucagonaemia, increased carbonmonoxide synthesis, and activation of KATP channels invascular smooth muscle cells in the systemic and splanchnicarterial circulation. Hydrogen sulphide (H2S) has recentlybeen identified as a novel gaseous transmitter that inducesvasodilatation through activation of KATP channels invascular smooth muscle cells. In this brief review, wecomment on what is known about H2S, vascular andneurological function, and postulate its role in thepathogenesis of the vascular abnormalities in cirrhosis.
| Type: | Article |
|---|---|
| Title: | Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/gut.2004.056556 |
| Additional information: | Imported via OAI, 7:29:01 2nd Dec 2005 |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Internal Medicine |
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