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Cytoplasmic dynein heavy chain: the servant of many masters.

Schiavo, G; Greensmith, L; Hafezparast, M; Fisher, EM; (2013) Cytoplasmic dynein heavy chain: the servant of many masters. Trends Neurosci , 36 (11) pp. 641-651. 10.1016/j.tins.2013.08.001. Green open access


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Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human patients that give rise to a broad spectrum of developmental and midlife-onset disorders. Here, we discuss the effects of mutations of mouse and human DYNC1H1 and how these studies are giving us new insight into the many critical roles DYNC1H1 plays in the nervous system.

Type: Article
Title: Cytoplasmic dynein heavy chain: the servant of many masters.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2013.08.001
Publisher version: http://dx.doi.org/10.1016/j.tins.2013.08.001
Additional information: �© 2013 The Authors. Published by Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Keywords: Cramping 1, Legs at odd angles, Sprawling, amyotrophic lateral sclerosis, axonal transport, motor neurons, neurodegeneration
URI: http://discovery.ucl.ac.uk/id/eprint/1406784
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