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Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions

Lanigan, RM; Sheppard, TD; (2013) Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions. European Journal of Organic Chemistry , 2013 (33) 7453 - 7465. 10.1002/ejoc.201300573. Green open access

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Abstract

The synthesis of amides is of huge importance in a wide variety of industrial and academic fields and is of particular significance in the synthesis of pharmaceuticals. Many of the well established methods for amide synthesis involve reagents that are difficult to handle and lead to the generation of large quantities of waste products. As a consequence, there has been a considerable amount of interest in the development of new approaches to amide synthesis. Over the past few years a wide range of new reagents and catalysts for direct amidation of carboxylic acids have been reported. In addition, the interconversion of amide derivatives through transamidation is emerging as a potential alternative strategy for accessing certain amides. This microreview covers recent developments in the direct amidation of carboxylic acids and the interconversion of amides through transamidation. The advantages and disadvantages of the various methods are discussed, as well as the possible mechanisms of the reactions.

Type: Article
Title: Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ejoc.201300573
Publisher version: http://dx.doi.org/10.1002/ejoc.201300573
Language: English
Additional information: This is the peer reviewed version of the following article: Lanigan, RM; Sheppard, TD; (2013) Recent developments in amide synthesis: direct amidation of carboxylic acids and transamidation reactions. European Journal of Organic Chemistry , 2013 (33) 7453 - 7465., which has been published in final form at http://dx.doi.org/10.1002/ejoc.201300573. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving
Keywords: Amides, Amines, Carboxylic acids, Amidation, Transamidation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/1405298
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