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Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report.

Mertin, J; Rudge, P; Kremer, M; Healey, MJ; Knight, SC; Compston, A; Batchelor, JR; ... Medawar, PB; + view all (1982) Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report. Lancet , 2 (8294) pp. 351-354. 10.1016/s0140-6736(82)90547-5.

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Abstract

In a double-blind controlled trial 43 patients with relapsing-remitting multiple sclerosis were treated either with anti-lymphocyte globulin, prednisolone, and azathioprine, or with placebo preparations. Treatment began with a combination of the three medicaments but after 1 month was continued for another 14 months with azathioprine (3 mg/kg dialy) only. There was a marginally beneficial effect of immunosuppression on the overall relapse rate and clinical progression. However, there were significant effects on in-vitro lymphocyte function and in the visual evoked potentials in favour of the group receiving suppressive treatment. Placebo-treated patients of the HLA A3 tissue type had significantly more relapses than placebo-treated patients who were not of type HLA A3. Nevertheless, HLA-A3-positive patients treated with immunosuppression had significantly fewer relapses than A3-positive placebo-treated patients.

Type: Article
Title: Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report.
Location: England
DOI: 10.1016/s0140-6736(82)90547-5
Keywords: Adolescent, Adult, Antilymphocyte Serum, Azathioprine, Clinical Trials as Topic, Double-Blind Method, Drug Therapy, Combination, Evoked Potentials, Visual, HLA Antigens, Histocompatibility Antigens Class II, Humans, Immunosuppressive Agents, Middle Aged, Multiple Sclerosis, Prednisolone, Random Allocation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/1404116
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