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Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms.

Castilla-Llorente, V; Nicastro, G; Ramos, A; (2013) Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms. Biochem Soc Trans , 41 (4) pp. 861-865. 10.1042/BST20130058.

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Abstract

Regulating the expression of individual miRNAs (microRNAs) is important for cell development and function. The up- or down-regulation of the processing of specific miRNA precursors to the mature active form represents one tool to control miRNA concentration and is mediated by proteins that recognize the terminal loop of the RNA precursors. Terminal loop recognition is achieved by the combined action of several RNA-binding domains. The proteins can then regulate the processing by recruiting RNA enzymes, changing the RNA structure and preventing or enhancing the accessibility and processing activity of the core processing complexes. The present review focuses on how terminal loop-binding proteins recognize their RNA targets and mediate their regulatory function(s), and highlights how terminal loop-mediated regulation relates to the broader regulation of mRNA metabolism.

Type: Article
Title: Terminal loop-mediated regulation of miRNA biogenesis: selectivity and mechanisms.
Location: England
DOI: 10.1042/BST20130058
Keywords: Humans, MicroRNAs, Nucleic Acid Conformation, RNA Precursors
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1403946
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