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Pergolide in late-stage Parkinson disease.

Lang, AE; Quinn, N; Brincat, S; Marsden, CD; Parkes, JD; (1982) Pergolide in late-stage Parkinson disease. Ann Neurol , 12 (3) pp. 243-247. 10.1002/ana.410120305.

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Abstract

Twenty-six patients with late-stage Parkinson disease were given 0.4 to 15 mg of pergolide mesylate daily in addition to, or as replacement for, levodopa or bromocriptine therapy. Despite treatment with individually determined optimum doses of levodopa, bromocriptine, and anticholinergics, they had shown response failure or fluctuating response. Forty percent (11 patients) were unable to tolerate pergolide. Nausea and vomiting, somnolence, and psychiatric disturbances were the most frequent side effects. Eleven of the remaining patients improved on pergolide, 2 were unchanged, and 2 were slightly worse. Among the patients who benefited, pergolide improved dose-related response fluctuations more than non-dose-related fluctuations, with a reduction in number and duration of "off" periods and improvement in quality of sleep and early morning akinesia but little change in freezing episodes. Despite treatment failure in many cases, pergolide is at present the best available drug for specific late-stage management problems.

Type: Article
Title: Pergolide in late-stage Parkinson disease.
Location: United States
DOI: 10.1002/ana.410120305
Keywords: Bromocriptine, Clinical Trials as Topic, Double-Blind Method, Drug Therapy, Combination, Ergolines, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease, Pergolide, Sleep Wake Disorders
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/1403878
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