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Concentrations of GABA and other amino acids in CSF from torsion dystonia patients.

Perry, TL; Hansen, S; Quinn, N; Marsden, CD; (1982) Concentrations of GABA and other amino acids in CSF from torsion dystonia patients. J Neurochem , 39 (4) pp. 1188-1191. 10.1111/j.1471-4159.1982.tb11514.x.

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Abstract

Free amino acid concentrations were measured by conventional amino acid analysis, and gamma-aminobutyric acid (GABA) concentrations were determined, by an ion-exchange fluorometric technique, in CSF specimens from 16 patients with torsion dystonias and in CSF from a large number of control subjects. The mean CSF GABA concentration of the dystonia patients (97 +/- 11 nmol/L) did not differ significantly from the means for CSF GABA in two groups of adult control subjects. Mean concentrations of all commonly determined amino compounds were normal in the CSF of torsion dystonia patients, except for ornithine, which was modestly but significantly reduced.

Type: Article
Title: Concentrations of GABA and other amino acids in CSF from torsion dystonia patients.
Location: England
DOI: 10.1111/j.1471-4159.1982.tb11514.x
Keywords: Adolescent, Adult, Aged, Amino Acids, Child, Dystonia Musculorum Deformans, Female, Fluorometry, Humans, Male, Middle Aged, gamma-Aminobutyric Acid
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
URI: http://discovery.ucl.ac.uk/id/eprint/1403876
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