UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Left ventricular diastolic function compared with T2*cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major

Westwood, MA; Wonke, B; Maceira, AM; Prescott, E; Walker, JM; Porter, JB; Pennell, DJ; (2005) Left ventricular diastolic function compared with T2*cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major. J MAGN RESON IMAGING , 22 (2) 229 - 233. 10.1002/jmri.20379.

Full text not available from this repository.

Abstract

Purpose: To compare left ventricular (LV) diastolic function with myocardial iron levels in beta thalassemia major (TM) patients, using cardiovascular magnetic resonance (CMR).Materials and Methods: We studied 67 regularly transfused patients with TM and 22 controls matched for age, gender, and body surface area. The early peak filling rate (EPFR) and atrial peak filling rate (APFR) were determined from high-temporal-resolution ventricular volume-time curves. Myocardial iron estimation was achieved using myocardial T2* measurements.Results: Myocardial iron loading was found in 46 TM patients (69%), in whom the EPFR correlated poorly with T2* (r = -0.20, P = 0.19). The APFR (r = 0.49, P < 0.001) and EPFR/APFR ratio (r = -0.62, P < 0.001) correlated better with T2*. The sensitivity of the diastolic parameters for detecting myocardial iron loading ranged from 4% (EPFR and APFR) to 17% (EPFR/APFR ratio).Conclusion: Myocardial iron overload results in diastolic myocardial dysfunction, but low sensitivity limits the use of a single estimation for early detection of iron overload, for which T2* has a superior categorical limit of normality.

Type: Article
Title: Left ventricular diastolic function compared with T2*cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major
DOI: 10.1002/jmri.20379
Keywords: cardiomyopathy, thalassemia, magnetic resonance imaging, diastolic function, iron overload, BETA-THALASSEMIA, DOPPLER-ECHOCARDIOGRAPHY, HEART-FAILURE, SURVIVAL, REPRODUCIBILITY, ABNORMALITIES, DEFEROXAMINE, TRANSFUSION, DYSFUNCTION, CHELATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/140371
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item