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Autosomal dominant Parkinson's disease and the route to new therapies.

Morris, HR; (2007) Autosomal dominant Parkinson's disease and the route to new therapies. Expert Rev Neurother , 7 (6) pp. 649-656. 10.1586/14737175.7.6.649.

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Abstract

The pathogenesis of Parkinson's disease (PD) is not understood and there are currently no accepted disease modifying, neuroprotective treatments. There are two autosomal dominant PD genes, leucine-rich repeat kinase (LRRK)2 and alpha-synuclein. LRRK2 mutations are very common in patients with PD, accounting for 40% of patients with sporadic, nonfamilial disease in some ethnic groups. Alpha-synuclein mutations are much less frequent, but the importance of alpha-synuclein has been confirmed by the demonstration of alpha-synuclein deposition as Lewy bodies in patients with PD and Lewy body dementia. Pathogenic mutations in alpha-synuclein accelerate the formation of oligomers and fibrils. Mutations in LRRK2 lead to an enhancement in LRRK2 kinase activity. The further study and understanding of the route by which alpha-synuclein and LRRK2 lead to PD, and how these processes can be therapeutically manipulated, is likely to lead to new disease-modifying treatments.

Type: Article
Title: Autosomal dominant Parkinson's disease and the route to new therapies.
Location: England
DOI: 10.1586/14737175.7.6.649
Keywords: Antiparkinson Agents, Clinical Trials as Topic, Genes, Dominant, Genetic Predisposition to Disease, Genetic Therapy, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Parkinson Disease, Protein-Serine-Threonine Kinases, alpha-Synuclein
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1402583
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