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A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

Castaneda, L; Wright, ZVF; Marculescu, C; Tran, TM; Chudasama, V; Maruani, A; Hull, EA; ... Baker, JR; + view all (2013) A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones. Tetrahedron Letters , 54 (27) 3493 -3495. 10.1016/j.tetlet.2013.04.088. Green open access

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Abstract

Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new synthesis of these reagents is described, along with the convenient transferability of the approach to dithiomaleimides and bromopyridazinediones.

Type: Article
Title: A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tetlet.2013.04.088
Publisher version: http://dx.doi.org/10.1016/j.tetlet.2013.04.088
Language: English
Additional information: Copyright © 2013 The Authors. Published by Elsevier Ltd. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Bromomaleimides, Thiomaleimides, Pyridazinediones, Reagent synthesis, Reagents for cysteine modification
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1402217
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