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Probabilistic segmentation propagation from uncertainty in registration

Simpson, IJA; Woolrich, MW; Schnabel, JA; (2011) Probabilistic segmentation propagation from uncertainty in registration. In: Proccedings Medical Image Analysis and Understanding (MIUA), 2011. Green open access

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In this paper we propose a novel approach for incorporating measures of spatial uncertainty which are derived from non-rigid registration, into propagated segmentation labels. In current approaches to segmentation via label propagation, a point-estimate of the registration parameters is used. However, this is limited by the registration accuracy achieved. In this work, we derive local measurements of the uncertainty of a non-rigid mapping from a probabilistic registration framework. This allows us to consider the set of probable locations for a segmentation label to hold. We demonstrate the use of this method on the propagation of accurately delineated cortical labels in inter-subject brain MRI using the NIREP dataset. We find that accounting for the spatial uncertainty of the mapping increases the sensitivity of correctly classifying anatomical labels.

Type: Proceedings paper
Title: Probabilistic segmentation propagation from uncertainty in registration
Event: Medical Image Understanding and Analysis 2011, King's College London Thursday 14th - Friday 15th July 2011.
Dates: 2011-06
Open access status: An open access version is available from UCL Discovery
Publisher version: http://biomedical-image-analysis.co.uk/images/stor...
Language: English
Additional information: © 2011. The copyright of this document resides with its authors. It may be distributed unchanged freely in print or electronic forms.
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
URI: http://discovery.ucl.ac.uk/id/eprint/1401757
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