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Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

Martinez, M; Brice, A; Vaughan, JR; Zimprich, A; Breteler, MMB; Meco, G; Filla, A; ... French Parkinson's Disease, ; + view all (2005) Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease. AM J MED GENET B , 136B (1) 72 - 74. 10.1002/ajmg.b.30196.

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Abstract

Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. (c) 2005 Wiley-Liss, Inc.

Type: Article
Title: Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
DOI: 10.1002/ajmg.b.30196
Keywords: Parkinson's disease, genetics, apolipoprotein E, E GENOTYPE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/140126
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