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Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.

Hapuarachchi, T; Moroz, T; Bainbridge, A; Price, D; Cady, E; Baer, E; Broad, K; ... Tachtsidis, I; + view all (2013) Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes. Adv Exp Med Biol , 789 331 - 337. 10.1007/978-1-4614-7411-1_44. Green open access

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Abstract

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

Type: Article
Title: Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating pH changes.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-1-4614-7411-1_44
Publisher version: http://dx.doi.org/10.1007/978-1-4614-7411-1_44
Language: English
Additional information: © Springer Science+Business Media New York 2013. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Keywords: Animals, Animals, Newborn, Brain, Cerebrovascular Circulation, Disease Models, Animal, Hydrogen-Ion Concentration, Hypoxia-Ischemia, Brain, Magnetic Resonance Spectroscopy, Models, Cardiovascular, Oxygen, Oxygen Consumption, Spectroscopy, Near-Infrared, Swine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1400801
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