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Perceptual judgements and chronic imaging of altered odour maps indicate comprehensive stimulus template matching in olfaction.

Bracey, EF; Pichler, B; Schaefer, AT; Wallace, DJ; Margrie, TW; (2013) Perceptual judgements and chronic imaging of altered odour maps indicate comprehensive stimulus template matching in olfaction. Nat Commun , 4 , Article 2100. 10.1038/ncomms3100. Green open access

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Abstract

Lesion experiments suggest that odour input to the olfactory bulb contains significant redundant signal such that rodents can discern odours using minimal stimulus-related information. Here we investigate the dependence of odour-quality perception on the integrity of glomerular activity by comparing odour-evoked activity maps before and after epithelial lesions. Lesions prevent mice from recognizing previously experienced odours and differentially delay discrimination learning of unrecognized and novel odour pairs. Poor recognition results not from mice experiencing an altered concentration of an odour but from perception of apparent novel qualities. Consistent with this, relative intensity of glomerular activity following lesions is altered compared with maps recorded in shams and by varying odour concentration. Together, these data show that odour recognition relies on comprehensively matching input patterns to a previously generated stimulus template. When encountering novel odours, access to all glomerular activity ensures rapid generation of new templates to perform accurate perceptual judgements.

Type: Article
Title: Perceptual judgements and chronic imaging of altered odour maps indicate comprehensive stimulus template matching in olfaction.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncomms3100
Publisher version: http://dx.doi.org/ doi:10.1038/ncomms3100
Language: English
Additional information: This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Keywords: Animals, Discrimination Learning, Judgment, Male, Mice, Mice, Inbred C57BL, Nasal Mucosa, Odors, Perception, Physical Stimulation, Recognition (Psychology), Smell, Zinc Sulfate
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: http://discovery.ucl.ac.uk/id/eprint/1399985
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