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Different levels of neuroprotection by two insulin-like growth factor-I splice variants

Aperghis, M; Johnson, IP; Cannon, J; Yang, SY; Goldspink, G; (2004) Different levels of neuroprotection by two insulin-like growth factor-I splice variants. BRAIN RES , 1009 (1-2) 213 - 218. 10.1016/j.brainres.2004.02.049.

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Abstract

We compared the neuroprotective effects of a liver-type isoform of insulin-like growth factor-I (IGF-IEa) and its splice variant, mechano-growth factor (MGF), isolated from active skeletal muscle. cDNAs of these peptides were injected into the facial muscle of adult rats prior to facial nerve avulsion. This resulted in significant neuroprotection of 88% and 37%, respectively, of motoneurons compared to control plasmid and avulsion-only groups. MGF is markedly more effective than the liver-type, systemic IGF-I for motoneuron survival, suggesting a major role for the peripheral target in adult neuronal maintenance and survival. (C) 2004 Elsevier B.V. All rights reserved.

Type:Article
Title:Different levels of neuroprotection by two insulin-like growth factor-I splice variants
DOI:10.1016/j.brainres.2004.02.049
Keywords:adult, avulsion, facial nerve, IGF-I, MGF, motoneuron, RAT SPINAL MOTONEURONS, ADENOVIRAL GENE-TRANSFER, VENTRAL ROOT AVULSION, STEM CELL ACTIVATION, NEUROTROPHIC FACTOR, FACIAL MOTONEURONS, ADULT MOTONEURONS, NEONATAL-RATS, IGF-I, MUSCLE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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