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Evolution of P2X receptors

Burnstock, G; Verkhratsky, A; (2012) Evolution of P2X receptors. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling , 1 (2) pp. 188-200. 10.1002/wmts.13.

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Abstract

Purines appear to be the most primitive and widespread chemical messengers in all kingdoms of the Domain Eucarya. There is evidence for purinergic signaling in plants, invertebrates, and lower vertebrates from protozoa to birds. Much is based on pharmacological studies, but important recent papers have utilized the techniques of molecular biology, and ATP-gated ion channels (ionotropic purinoceptors) have been cloned and characterized in primitive invertebrates, including the social amoeba Dictyostelium and the platyhelminth Schistosoma, as well as the green algae Ostreococcus. These ancient purinoceptors resemble P2X receptors identified in mammals. This suggests that contrary to earlier speculations, P2X ion channel receptors appeared early in evolution, while G protein-coupled P1 and P2Y receptors were introduced either at the same time or perhaps even later. The absence of gene coding for P2X receptors in some animal groups (e.g., in some insects, roundworm Caenorhabditis elegans, and the plant Arabidopsis), in contrast to the potent pharmacological actions of nucleotides in the same species, suggests that novel receptors are still to be discovered. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Type: Article
Title: Evolution of P2X receptors
DOI: 10.1002/wmts.13
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1399162
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