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Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice

Riddoch-Contreras, J; Yang, SY; Dick, JRT; Goldspink, G; Orrell, RW; Greensmith, L; (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. EXP NEUROL , 215 (2) 281 - 289. 10.1016/j.expneurol.2008.10.014.

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Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motoneuron degeneration. Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results. Here we examine the effects of an IGF-I splice variant, mechano-growth factor (MGF) which has previously been shown to have greater neuroprotective effects than IGF-I in a number of models of neurodegeneration. A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset. Treatment with either IGF-I or MGF resulted in a significant improvement in hindlimb muscle strength, and an increase in motor unit and motoneuron Survival. Significantly more motoneurons survived in MGF treated mice. (c) 2008 Elsevier Inc. All rights reserved.

Type:Article
Title:Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice
DOI:10.1016/j.expneurol.2008.10.014
Keywords:Neurotrophic factors, Motoneuron survival, Motor neuron disease, Therapy, Skeletal muscle, Neuroprotection, Amyotrophic lateral sclerosis, IGF-I, MGF, AMYOTROPHIC-LATERAL-SCLEROSIS, SKELETAL-MUSCLE, MOUSE MODEL, DISEASE PROGRESSION, ALS MICE, EXPRESSION, CELL, SURVIVAL, DELIVERY, PEPTIDE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Motor Neuroscience and Movement Disorders
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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