Riddoch-Contreras, J; Yang, SY; Dick, JRT; Goldspink, G; Orrell, RW; Greensmith, L; (2009) Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice. EXP NEUROL , 215 (2) 281 - 289. 10.1016/j.expneurol.2008.10.014.
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motoneuron degeneration. Although viral delivery of IGF-I has shown therapeutic efficacy in the SOD1(G93A) mouse model of ALS, clinical trials of IGF-I in ALS patients have led to conflicting results. Here we examine the effects of an IGF-I splice variant, mechano-growth factor (MGF) which has previously been shown to have greater neuroprotective effects than IGF-I in a number of models of neurodegeneration. A mammalian expression plasmid containing either MGF or, for comparison, the IGF-I cDNA sequence was delivered to the hindlimb muscles of SOD1(G93A) mice at 70 days of age, at symptom onset. Treatment with either IGF-I or MGF resulted in a significant improvement in hindlimb muscle strength, and an increase in motor unit and motoneuron Survival. Significantly more motoneurons survived in MGF treated mice. (c) 2008 Elsevier Inc. All rights reserved.
|Title:||Mechano-growth factor, an IGF-I splice variant, rescues motoneurons and improves muscle function in SOD1(G93A) mice|
|Keywords:||Neurotrophic factors, Motoneuron survival, Motor neuron disease, Therapy, Skeletal muscle, Neuroprotection, Amyotrophic lateral sclerosis, IGF-I, MGF, AMYOTROPHIC-LATERAL-SCLEROSIS, SKELETAL-MUSCLE, MOUSE MODEL, DISEASE PROGRESSION, ALS MICE, EXPRESSION, CELL, SURVIVAL, DELIVERY, PEPTIDE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Clinical Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Motor Neuroscience and Movement Disorders
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
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