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Preoperative assessment of ovarian tumors by CA 125 measurement and transvaginal color Doppler ultrasound.

Kupesić, S; Vujisić, S; Kurjak, A; Mihaljević, D; Radosević, S; (2002) Preoperative assessment of ovarian tumors by CA 125 measurement and transvaginal color Doppler ultrasound. Acta Med Croatica , 56 (1) pp. 3-10.

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Abstract

The accuracy of combined use of serum CA 125 and transvaginal color Doppler for preoperative assessment of ovarian lesions in premenopausal patients was evaluated. Seventy-six ovarian lesions were analyzed the day before surgery using transvaginal color Doppler ultrasound. On the same day, serum CA 125 was measured in each patient. A novel index is proposed for the detection of ovarian malignancy combining resistance index (RI) obtained from newly formed vessels within the ovarian lesion and serum CA 125 level: (RI/CA 125) x 100. Values below the cut-off value of 1.5 were associated with a high risk of ovarian malignancy. Assessment of ovarian lesions by the novel index had a sensitivity and specificity of 94.44% and 100%, while positive and negative predictive values were 100% and 98.31%, respectively. The best prediction of ovarian malignancy was achieved by a combined use of transvaginal color Doppler ultrasound and serum CA 125 in the form of index: (RI/CA 125) x 100.

Type: Article
Title: Preoperative assessment of ovarian tumors by CA 125 measurement and transvaginal color Doppler ultrasound.
Location: Croatia
Keywords: Adult, CA-125 Antigen, Cystadenocarcinoma, Diagnosis, Differential, Female, Humans, Middle Aged, Ovarian Diseases, Ovarian Neoplasms, Predictive Value of Tests, Premenopause, Sensitivity and Specificity, Ultrasonography, Doppler, Color
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > SSEES
URI: http://discovery.ucl.ac.uk/id/eprint/1398658
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