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Chase-and-run between adjacent cell populations promotes directional collective migration

Theveneau, E; Steventon, B; Scarpa, E; Garcia, S; Trepat, X; Streit, A; Mayor, R; (2013) Chase-and-run between adjacent cell populations promotes directional collective migration. Nature Cell Biology , 15 (7) pp. 763-772. 10.1038/ncb2772. Green open access

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Abstract

Collective cell migration in morphogenesis and cancer progression often involves the coordination of multiple cell types. How reciprocal interactions between adjacent cell populations lead to new emergent behaviours remains unknown. Here we studied the interaction between neural crest (NC) cells, a highly migratory cell population, and placodal cells, an epithelial tissue that contributes to sensory organs. We found that NC cells chase placodal cells by chemotaxis, and placodal cells run when contacted by NC. Chemotaxis to Sdf1 underlies the chase, and repulsion involving PCP and N-cadherin signalling is responsible for the run. This chase-and-run requires the generation of asymmetric forces, which depend on local inhibition of focal adhesions. The cell interactions described here are essential for correct NC migration and for segregation of placodes in vivo and are likely to represent a general mechanism of coordinated migration.

Type: Article
Title: Chase-and-run between adjacent cell populations promotes directional collective migration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncb2772
Publisher version: http://dx.doi.org/10.1038/ncb2772
Language: English
Additional information: Copyright © 2013 Macmillan Publishers Limited. All rights reserved.
Keywords: Animals, Cadherins, Cell Communication, Cell Movement, Cells, Cultured, Chemokine CXCL12, Chemotaxis, Embryo, Mammalian, Epithelial Cells, Focal Adhesions, Guanine Nucleotide Exchange Factors, Mice, Neural Crest, Signal Transduction, Time-Lapse Imaging
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1398172
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