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Systems biology approaches to finding novel pain mediators

Antunes-Martins, A; Perkins, JR; Lees, J; Hildebrandt, T; Orengo, C; Bennett, DL; (2013) Systems biology approaches to finding novel pain mediators. Wiley Interdiscip Rev Syst Biol Med , 5 (1) 11-35+-11-35+. 10.1002/wsbm.1192%20%5Bdoi%5D.

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Abstract

Chronic pain represents a major health burden; this maladaptive pain state occurs as a consequence of hypersensitivity within the peripheral and central components of the somatosensory system. High throughput technologies (genomics, transciptomics, lipidomics, and proteomics) are now being applied to tissue derived from pain patients as well as experimental pain models to discover novel pain mediators. The use of clustering, meta-analysis and other techniques can help refine potential candidates. Of particular importance are systems biology methods, such as co-expression network generating algorithms, which infer potential associations/interactions between molecules and build networks based on these interactions. Protein-protein interaction networks allow the lists of potential targets generated by these different platforms to be analyzed in their biological context. Outputs from these different methods must also be related to the clinical pain phenotype. The improved and standardized phenotyping of pain symptoms and sensory signs enables much better subject stratification. Our hope is that, in the future, the use of computational approaches to integrate datasets including sensory phenotype as well as the outputs of high throughput technologies will help define novel pain mediators and provide insights into the pathogenesis of chronic pain.

Type: Article
Title: Systems biology approaches to finding novel pain mediators
DOI: 10.1002/wsbm.1192%20%5Bdoi%5D
Publisher version: http://dx.doi.org/10.1002/wsbm.1192%20%5Bdoi%5D
Additional information: citeulike-article-id: 12411851 citeulike-linkout-0: http://dx.doi.org/10.1002/wsbm.1192%20%5Bdoi%5D comment: eng —=note-separator=— Nlm —=note-separator=— Antunes-Martins, Ana Perkins, James R Lees, Jonathan Hildebrandt, Tobias Orengo, Christine Bennett, David L H Research Support, Non-U.S. Gov’t Review United States Wiley interdisciplinary reviews. Systems biology and medicine Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):11-35. doi: 10.1002/wsbm.1192. Epub 2012 Oct 11. —=note-separator=— Systems biology approaches to finding novel pain mediators —=note-separator=— Jan-Feb keywords: analgesics-, animals, biological, biology-, chronic, computer, discovery-, drug, humans, metabolism, methods, models, pain-, physiopathology, proteome-, simulation, systems, therapeutic, therapy-, use, *file-import-13-06-12 posted-at: 2013-06-12 22:01:28 priority: 2 bdsk-url-1: http://dx.doi.org/10.1002/wsbm.1192%5C%20%5C%5Bdoi%5C%5D bdsk-url-2: http://dx.doi.org/10.1002/wsbm.1192%5C%2520%5C%255Bdoi%5C%255D
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1396633
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