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FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies

Furnham, N; Sillitoe, I; Holliday, GL; Cuff, AL; Rahman, SA; Laskowski, RA; Orengo, CA; (2012) FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies. Nucleic Acids Res , 40 (Database) D776-82+-D776-82+. 10.1093/nar/gkr852%20%5Bdoi%5D.

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Abstract

FunTree is a new resource that brings together sequence, structure, phylogenetic, chemical and mechanistic information for structurally defined enzyme superfamilies. Gathering together this range of data into a single resource allows the investigation of how novel enzyme functions have evolved within a structurally defined superfamily as well as providing a means to analyse trends across many superfamilies. This is done not only within the context of an enzyme’s sequence and structure but also the relationships of their reactions. Developed in tandem with the CATH database, it currently comprises 276 superfamilies covering 1800 (70%) of sequence assigned enzyme reactions. Central to the resource are phylogenetic trees generated from structurally informed multiple sequence alignments using both domain structural alignments supplemented with domain sequences and whole sequence alignments based on commonality of multi-domain architectures. These trees are decorated with functional annotations such as metabolite similarity as well as annotations from manually curated resources such the catalytic site atlas and MACiE for enzyme mechanisms. The resource is freely available through a web interface: www.ebi.ac.uk/thorton-srv/databases/FunTree.

Type: Article
Title: FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies
DOI: 10.1093/nar/gkr852%20%5Bdoi%5D
Publisher version: http://dx.doi.org/10.1093/nar/gkr852%20%5Bdoi%5D
Additional information: citeulike-article-id: 12411843 citeulike-linkout-0: http://dx.doi.org/10.1093/nar/gkr852%20%5Bdoi%5D comment: eng —=note-separator=— Nlm —=note-separator=— Furnham, Nicholas Sillitoe, Ian Holliday, Gemma L Cuff, Alison L Rahman, Syed A Laskowski, Roman A Orengo, Christine A Thornton, Janet M 081989/Z/07/A/Wellcome Trust/United Kingdom Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov’t Research Support, U.S. Gov’t, Non-P.H.S. England Nucleic acids research Nucleic Acids Res. 2012 Jan;40(Database issue):D776-82. doi: 10.1093/nar/gkr852. Epub 2011 Oct 17. —=note-separator=— FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies —=note-separator=— Jan keywords: alignment, analysis, biological, chemistry-, classification-metabolism, databases, enzymes-, evolution, phylogeny, protein, sequence, structure, tertiary, *file-import-13-06-12 posted-at: 2013-06-12 22:01:27 priority: 2 bdsk-url-1: http://dx.doi.org/10.1093/nar/gkr852%5C%20%5C%5Bdoi%5C%5D bdsk-url-2: http://dx.doi.org/10.1093/nar/gkr852%5C%2520%5C%255Bdoi%5C%255D
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1396627
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