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Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders

Detera-Wadleigh, SD; Goldin, LR; Sherrington, R; Encio, I; de Miguel, C; Berrettini, W; Gurling, H; (1989) Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders. Nature , 340 pp. 391-393. 10.1038/340391a0.

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Abstract

Recently a linkage study on five Icelandic and two English pedigrees has provided evidence for a dominant gene for schizophrenia on 5q11-13 (ref. 1). In that study, families with bipolar illness were not included. Using the same probes, two similar but independent investigations on one Swedish pedigree and on fifteen Scottish families excluded linkage to schizophrenia. To evaluate whether the susceptibility gene on 5q11-13 is a common cause of schizophrenia in other populations, we examined five affected North American pedigrees using probes to the D5S39, D5S76 and dihydrofolate reductase loci. Two families in the present series had cases of bipolar disorder. We found that linkage can be excluded by multipoint analysis. These results, taken together, suggest that the disease gene on 5q11-13 does not account for most cases of familial schizophrenia.

Type: Article
Title: Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders
DOI: 10.1038/340391a0
Additional information: Detera-Wadleigh, S D Goldin, L R Sherrington, R Encio, I de Miguel, C Berrettini, W Gurling, H Gershon, E S eng ENGLAND 1989/08/03 Nature. 1989 Aug 3;340(6232):391-3. Recently a linkage study on five Icelandic and two English pedigrees has provided evidence for a dominant gene for schizophrenia on 5q11-13 (ref. 1). In that study, families with bipolar illness were not included. Using the same probes, two similar but independent investigations on one Swedish pedigree and on fifteen Scottish families excluded linkage to schizophrenia. To evaluate whether the susceptibility gene on 5q11-13 is a common cause of schizophrenia in other populations, we examined five affected North American pedigrees using probes to the D5S39, D5S76 and dihydrofolate reductase loci. Two families in the present series had cases of bipolar disorder. We found that linkage can be excluded by multipoint analysis. These results, taken together, suggest that the disease gene on 5q11-13 does not account for most cases of familial schizophrenia.
Keywords: Bipolar Disorder/*genetics *Chromosomes, Human, Pair 5 Exons *Genetic Linkage Humans Introns Lod Score Pedigree Polymorphism, Genetic Schizophrenia/*genetics Tetrahydrofolate Dehydrogenase/genetics
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1395448
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