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Tumour heterogeneity and immune-modulation.

Jamal-Hanjani, M; Thanopoulou, E; Peggs, KS; Quezada, SA; Swanton, C; (2013) Tumour heterogeneity and immune-modulation. Curr Opin Pharmacol , 13 (4) 497 - 503. 10.1016/j.coph.2013.04.006. Green open access

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Abstract

Recent advances in sequencing technologies have revealed extensive intratumour heterogeneity (ITH) both within individual tumours and between primary and metastatic tumours for different cancer types. Such genetic diversity may have clinical implications for both cancer diagnosis and treatment with increasing evidence linking ITH and therapeutic resistance. Nonetheless, whilst limiting the activity of targeted agents, tumour genetic heterogeneity may provide a new therapeutic opportunity through generation of neo-antigens that could be recognised and targeted by the patient's own immune system in response to immune-modulatory therapies. Longitudinal genomic studies assessing tumour clonal architecture and its correlation with the underlying immune response to cancer in each particular patient are needed to follow tumour evolutionary dynamics over time and through therapy, in order to further understand the mechanisms behind drug resistance and to inform the development of new combinatorial therapeutic strategies.

Type: Article
Title: Tumour heterogeneity and immune-modulation.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coph.2013.04.006
Publisher version: http://dx.doi.org/10.1016/j.coph.2013.04.006
Language: English
Additional information: © 2013 Elsevier Ltd. All rights. This work is licensed under a Creative Commons Attribution 3.0 Unported License. PMCID: PMC3988963
Keywords: Clonal Evolution, Genetic Heterogeneity, Humans, Immunomodulation, Neoplasms
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1395304
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