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Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.

Manzoni, C; Lewis, PA; (2013) Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies. The FASEB Journal , 27 (9) 3424 - 3429. 10.1096/fj.12-223842. Green open access

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Abstract

The past decade has witnessed huge advances in our understanding of the genetics underlying Parkinson's disease. Identifying commonalities in the biological function of genes linked to Parkinson's provides an opportunity to elucidate pathways that lead to neuronal degeneration and eventually to disease. We propose that the genetic forms of Parkinson's disease largely associated with α-synuclein-positive neuropathology (SNCA, LRRK2, and GBA) are brought together by involvement in the autophagy/lysosomal pathway and that this represents a unifying pathway to disease in these cases.

Type: Article
Title: Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1096/fj.12-223842
Publisher version: http://dx.doi.org/10.1096/fj.12-223842
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) (http://creativecommons.org/licenses/by/3.0/deed. en_US) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: GBA, LRRK2, Parkinson's disease, Animals, Autophagy, Humans, Lysosomes, Models, Biological, Nerve Degeneration, Parkinson Disease, alpha-Synuclein
URI: http://discovery.ucl.ac.uk/id/eprint/1393937
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