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Complement in animal development: unexpected roles of a highly conserved pathway.

Leslie, JD; Mayor, R; (2013) Complement in animal development: unexpected roles of a highly conserved pathway. Semin Immunol , 25 (1) 39 - 46. 10.1016/j.smim.2013.04.005. Green open access

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Abstract

The complement pathway is most famous for its role in immunity, orchestrating an exquisitely refined system for immune surveillance. At its core lies a cascade of proteolytic events that ultimately serve to recognise microbes, infected cells or debris and target them for elimination. Mounting evidence has shown that a number of the proteolytic intermediaries in this cascade have, in themselves, other functions in the body, signalling through receptors to drive events that appear to be unrelated to immune surveillance. It seems, then, that the complement system not only functions as an immunological effector, but also has cell-cell signalling properties that are utilised by a number of non-immunological processes. In this review we examine a number of these processes in the context of animal development, all of which share a requirement for precise control of cell behaviour in time and space. As we will see, the scope of the complement system's function is indeed much greater than we might have imagined only a few years ago.

Type: Article
Title: Complement in animal development: unexpected roles of a highly conserved pathway.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.smim.2013.04.005
Publisher version: http://dx.doi.org/10.1016/j.smim.2013.04.005
Language: English
Additional information: © 2013 Elsevier Ltd. Open access under CC BY license. PMCID: PMC3989114
Keywords: Chemotaxis, Co-attraction, Collective cell migration, Complement, Development, Synapse elimination, Animals, Cell Communication, Cell Movement, Complement System Proteins, Electrical Synapses, Humans, Immunologic Surveillance, Morphogenesis, Regeneration, Signal Transduction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1393791
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