Humphray, SJ; Oliver, K; Hunt, AR; Plumb, RW; Loveland, JE; Howe, KL; ... Dunham, I; + view all Humphray, SJ; Oliver, K; Hunt, AR; Plumb, RW; Loveland, JE; Howe, KL; Andrews, TD; Searle, S; Hunt, SE; Scott, CE; Jones, MC; Ainscough, R; Almeida, JP; Ambrose, KD; Ashwell, RIS; Babbage, AK; Babbage, S; Bagguley, CL; Bailey, J; Banerjee, R; Barker, DJ; Barlow, KF; Bates, K; Beasley, H; Beasley, O; Bird, CP; Bray-Allen, S; Brown, AJ; Brown, JY; Burford, D; Burrill, W; Burton, J; Carder, C; Carter, NP; Chapman, JC; Chen, Y; Clarke, G; Clark, SY; Clee, CM; Clegg, S; Collier, RE; Corby, N; Crosier, M; Cummings, AT; Davies, J; Dhami, P; Dunn, M; Dutta, I; Dyer, LW; Earthrowl, ME; Faulkner, L; Fleming, CJ; Frankish, A; Frankland, JA; French, L; Fricker, DG; Garner, P; Garnett, J; Ghori, J; Gilbert, JGR; Glison, C; Grafham, DV; Gribble, S; Griffiths, C; Jones, SG; Grocock, R; Guy, J; Hall, RE; Hammond, S; Harley, JL; Harrison, ESI; Hart, EA; Heath, PD; Henderson, CD; Hopkins, BL; Howard, PJ; Howden, PJ; Huckle, E; Johnson, C; Johnson, D; Joy, AA; Kay, M; Keenan, S; Kershaw, JK; Kimberley, AM; King, A; Knights, A; Laird, GK; Langford, C; Lawlor, S; Leongamornlert, DA; Leversha, M; Lloyd, C; Lloyd, DM; Lovell, J; Martin, S; Mashreghi-Mohammadi, M; Matthews, L; McLaren, S; McLay, KE; McMurray, A; Milne, S; Nickerson, T; Nisbett, J; Nordsiek, G; Pearce, AV; Peck, AI; Porter, KM; Pandian, R; Pelan, S; Phillimore, B; Povey, S; Ramsey, Y; Rand, V; Scharfe, M; Sehra, HK; Shownkeen, R; Sims, SK; Skuce, CD; Smith, M; Steward, CA; Swarbreck, D; Sycamore, N; Tester, J; Thorpe, A; Tracey, A; Tromans, A; Thomas, DW; Wall, M; Wallis, JM; West, AP; Whitehead, SL; Willey, DL; Williams, SA; Wilming, L; Wray, PW; Young, L; Ashurst, JL; Coulson, A; Blocker, H; Durbin, R; Sulston, JE; Hubbard, T; Jackson, MJ; Bentley, DR; Beck, S; Rogers, J; Dunham, I; - view fewer (2004) DNA sequence and analysis of human chromosome 9. NATURE , 429 (6990) 369 - 374. 10.1038/nature02465.
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Chromosome 9 is highly structurally polymorphic. It contains the largest autosomal block of heterochromatin, which is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the population. The finished euchromatic sequence of chromosome 9 comprises 109,044,351 base pairs and represents >99.6% of the region. Analysis of the sequence reveals many intra- and interchromosomal duplications, including segmental duplications adjacent to both the centromere and the large heterochromatic block. We have annotated 1,149 genes, including genes implicated in male-to-female sex reversal, cancer and neurodegenerative disease, and 426 pseudogenes. The chromosome contains the largest interferon gene cluster in the human genome. There is also a region of exceptionally high gene and G + C content including genes paralogous to those in the major histocompatibility complex. We have also detected recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection.
|Title:||DNA sequence and analysis of human chromosome 9|
|Keywords:||HUMAN GENOME SEQUENCE, BCR-ABL, SEGMENTAL DUPLICATIONS, PHYSICAL MAPS, GENE, EVOLUTION, REGION, HUMAN-CHROMOSOME-20, HETEROCHROMATIN, RECOMBINATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
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