UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

The DNA sequence and comparative analysis of human chromosome 10

Deloukas, P; Earthrowl, ME; Grafham, DV; Rubenfield, M; French, L; Steward, CA; ... Rogers, J; + view all (2004) The DNA sequence and comparative analysis of human chromosome 10. NATURE , 429 (6990) 375 - 381. 10.1038/nature02462.

Full text not available from this repository.

Abstract

The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentromeric region of the short and long arm of the chromosome. Sequence annotation revealed 1,357 genes, of which 816 are protein coding, and 430 are pseudogenes. We observed widespread occurrence of overlapping coding genes ( either strand) and identified 67 antisense transcripts. Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on the gene count on chromosome 10. Multispecies comparative analysis indicated that we can readily annotate the protein-coding genes with current resources. We estimate that over 95% of all coding exons were identified in this study. Assessment of single base changes between the human chromosome 10 and chimpanzee sequence revealed nonsense mutations in only 21 coding genes with respect to the human sequence.

Type:Article
Title:The DNA sequence and comparative analysis of human chromosome 10
DOI:10.1038/nature02462
Keywords:HUMAN GENOME SEQUENCE, PERICENTROMERIC SATELLITES, TRANSCRIPTIONAL PROFILE, SEGMENTAL DUPLICATIONS, PROSTATE-CANCER, PHYSICAL MAPS, GENE, PTEN, HUMAN-CHROMOSOME-20, RECOMBINATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

Archive Staff Only: edit this record