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Computer simulation of penetrant concentration-depth profiles in the stratum corneum

Watkinson, AC; Bunge, AL; Hadgraft, J; Naik, A; (1992) Computer simulation of penetrant concentration-depth profiles in the stratum corneum. International Journal of Pharmaceutics , 87 (1-3) pp. 175-182. 10.1016/0378-5173(92)90241-S.

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Abstract

Approximate drug concentration-depth profiles in the stratum corneum (sc) have been achieved by computer simulation. In vivo data from the literature have been used to predict profiles for cases where the diffusion coefficient is not constant with depth. The effects of a penetration enhancer (oleic acid) on the profiles have been modelled using this technique. The results indicate that, except in the presence of an enhancer, the profiles are little altered by a position-dependent diffusion coefficient. It has been demonstrated that it is not necessarily correct to assume a logarithmic type fit to concentration-depth data collected from tape strip experiments. © 1992.

Type: Article
Title: Computer simulation of penetrant concentration-depth profiles in the stratum corneum
DOI: 10.1016/0378-5173(92)90241-S
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: http://discovery.ucl.ac.uk/id/eprint/1390459
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