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An electron spin resonance study of skin penetration enhancers

(1989) An electron spin resonance study of skin penetration enhancers. International Journal of Pharmaceutics , 49 (1) pp. 39-45. 10.1016/0378-5173(89)90150-6.

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Abstract

The structured intercellular lipids of the stratum corneum are thought to play an important role in controlling the transport of drugs across the skin. In this study, multilamellar dipalmitoylphosphatidylcholine liposomes were used as a model of structured lipids. The effect of temperature and skin penetration enhancers on the lipid bilayer, was assessed using a spin labelling technique, in which 5-doxyl stearic acid was incorporated into the bilayer. The order parameter (S) of the spin label was calculated from the observed spectra. An increase in temperature decreased the order parameter. This decrease is due to increased rotational movement of the acyl chain of the spin label about its long molecular axis. It indicates a decrease in order within the bilayer structure, as a result of increased flexibility of the lipid molecules. Known skin penetration enhancers, Brij 36T, n-decylmethyl sulphoxide and oleic acid, also decreased the order parameter of the spin label. The penetration enhancer N-methyl-2-pyrrolidone had no significant effect. The results obtained were confirmed using a light scattering technique, in which the phase transition temperature of the liposomes was monitored in the presence and absence of the enhancers. 5-Doxyl stearic acid was incorporated into stratum corneum, separated from human cadaver skin. The spectra obtained were similar to those of the liposomal samples and the application of n-decylmethyl sulphoxide had a similar effect on the order parameter. © 1989.

Type: Article
Title: An electron spin resonance study of skin penetration enhancers
DOI: 10.1016/0378-5173(89)90150-6
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
URI: http://discovery.ucl.ac.uk/id/eprint/1390449
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