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Pharmacokinetics of percutaneous absorption with concurrent metabolism

Guy, RH; Hadgraft, J; (1984) Pharmacokinetics of percutaneous absorption with concurrent metabolism. International Journal of Pharmaceutics , 20 (1-2) pp. 43-51. 10.1016/0378-5173(84)90216-3.

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Abstract

A pharmacokinetic model for percutaneous absorption has been formulated which allows calculation of the drug disposition in the skin, plasma and urine. Allowance is also made for metabolic processes within the skin. The influence of metabolism on the concentrations of the parent molecule and the metabolite in the plasma is discussed. © 1984.

Type: Article
Title: Pharmacokinetics of percutaneous absorption with concurrent metabolism
DOI: 10.1016/0378-5173(84)90216-3
URI: http://discovery.ucl.ac.uk/id/eprint/1390434
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