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Peripheral neural detection of danger-associated and pathogen-associated molecular patterns.

Ackland, GL; Kazymov, V; Marina, N; Singer, M; Gourine, AV; (2013) Peripheral neural detection of danger-associated and pathogen-associated molecular patterns. Crit Care Med , 41 (6) e85 - e92. 10.1097/CCM.0b013e31827c0b05. Green open access

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Abstract

Bidirectional links between the nervous and immune systems modulate inflammation. The cellular mechanisms underlying the detection of danger-associated molecular patterns and pathogen-associated molecular patterns by the nervous system are not well understood. We hypothesized that the carotid body, a tissue of neural crest origin, detect pathogen associated molecular patterns and danger associated molecular patterns via an inflammasome-dependent mechanism similar to that described in immune cells.

Type: Article
Title: Peripheral neural detection of danger-associated and pathogen-associated molecular patterns.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/CCM.0b013e31827c0b05
Publisher version: http://dx.doi.org/10.1097/CCM.0b013e31827c0b05
Language: English
Additional information: © 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC4154842
Keywords: Animals, Calcium, Carotid Body, Carotid Sinus, Disease Models, Animal, Humans, Inflammation Mediators, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Neutrophils, Random Allocation, Rats, Rats, Sprague-Dawley, Toll-Like Receptors, Zymosan
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1389784
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