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Calfacilitin is a calcium channel modulator essential for initiation of neural plate development.

Papanayotou, C; De Almeida, I; Liao, P; Oliveira, NM; Lu, SQ; Kougioumtzidou, E; Zhu, L; ... Stern, CD; + view all (2013) Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. Nature Communications , 4 , Article 1837. 10.1038/ncomms2864. Green open access

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Abstract

Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CaV1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling.

Type: Article
Title: Calfacilitin is a calcium channel modulator essential for initiation of neural plate development.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/ncomms2864
Publisher version: http://dx.doi.org/10.1038/ncomms2864
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence (CC BY), which permits which permits users to share (copy, distribute and transmit) and remix (adapt) the contribution including for commercial purposes provided the original work is correctly attributed. http://creativecommons.org/licenses/by/3.0/
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/1389054
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