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Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescents

Singhal, A; Jamieson, N; Fewtrell, M; Deanfield, J; Lucas, A; Sattar, N; (2005) Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescents. J CLIN ENDOCR METAB , 90 (8) 4615 - 4621. 10.1210/jc.2005-0131.

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Abstract

Background: Adiponectin, an adipocyte-derived hormone found in lower concentration with greater adiposity, is suggested to reduce the risk of insulin resistance, atherosclerosis, and cardiovascular disease. We tested this hypothesis in a healthy, nonobese population.Methods and Results: Brachial artery flow-mediated endothelialdependent vasodilation and distensibility, measures of vascular function relevant to the early atherosclerotic process, were determined in 294 adolescents (aged 13-16 yr) using high-resolution vascular ultrasound. Fasting insulin concentration and the homeostasis model assessment of insulin resistance were used to estimate insulin resistance. Fat mass was measured by bioelectric impedance analysis; fasting serum adiponectin concentration by RIA; and lipid profile, fasting insulin, glucose, and C-reactive protein concentrations using standard laboratory techniques. Adiponectin concentration was associated with insulin resistance independent of potential confounding factors (e.g. -1.3% change in fasting insulin concentration per 10% increase in adiponectin concentration; 95% confidence interval, -2.4% to -0.1%; P = 0.03), but not with flow-mediated endothelialdependent vasodilation or arterial distensibility.Conclusions: Lower adiponectin concentration was associated with lower insulin sensitivity in a healthy, nonobese population. Our study supports the hypothesis that adiponectin benefits insulin sensitivity from a young age but, in contrast to experimental models and data from older subjects, does not affect vascular changes associated with early atherosclerosis.

Type: Article
Title: Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescents
DOI: 10.1210/jc.2005-0131
Keywords: VASCULAR FUNCTION, ARTERIAL DISTENSIBILITY, PROTEIN ADIPONECTIN, PLASMA-PROTEIN, OBESE CHILDREN, HYPOADIPONECTINEMIA, DYSFUNCTION, POPULATION, ASSOCIATION, DISEASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: http://discovery.ucl.ac.uk/id/eprint/138664
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