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Targeting VEGF signalling via the neuropilin co-receptor.

Djordjevic, S; Driscoll, PC; (2013) Targeting VEGF signalling via the neuropilin co-receptor. Drug Discovery Today , 18 (9-10) 447 - 455. 10.1016/j.drudis.2012.11.013. Green open access

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Abstract

The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug development in oncology and other pathologies. Historically, targeting vascular endothelial growth factor (VEGF) activity and its association with VEGF receptors (VEGFRs) has represented the most promising line of attack. More recently, the recognition that VEGFR co-receptors, neuropilin-1 and -2 (NRP1 and NRP2), are also engaged by specific VEGF isoforms in tandem with the VEGFRs has expanded the landscape for the development of modulators of VEGF-dependent signalling. Here, we review the recent structural characterisation of VEGF interactions with NRP subdomains and the impact this has had on drug development activity in this area.

Type: Article
Title: Targeting VEGF signalling via the neuropilin co-receptor.
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.drudis.2012.11.013
Publisher version: http://dx.doi.org/10.1016/j.drudis.2012.11.013
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1386313
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