Hooton, H;
Angquist, L;
Holst, C;
Hager, J;
Rousseau, F;
Hansen, RD;
Tjønneland, A;
... Clément, K; + view all
(2012)
Dietary factors impact on the association between CTSS variants and obesity related traits.
PLoS One
, 7
(7)
, Article e40394. 10.1371/journal.pone.0040394.
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Abstract
Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology--this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors--increased by high protein, glycemic index and energy diets.
| Type: | Article |
|---|---|
| Title: | Dietary factors impact on the association between CTSS variants and obesity related traits. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0040394 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0040394 |
| Language: | English |
| Additional information: | © 2012 Hooton et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This project was funded by two European grants: the DIOGENES grant and the GENDINOB grant. Work on Cathepsins in Nutriomique laboratory is supported by Region Ile de France (CODDIM), Fondation pour la recherche médicale/Danone and l’Agence Nationale de la Recherche (Programme OBCAT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The funders simply provided the funds for the study. FR is employed by INTEGRAGEN Paris France, the genomics company that performed the genotyping. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials. |
| Keywords: | Basal Metabolism, Body Fat Distribution, Body Mass Index, Body Weight, Cathepsins, Cohort Studies, Diet, Dietary Proteins, Female, Glycemic Index, Humans, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide |
| UCL classification: | UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1385211 |
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