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The Relationships of ABCB1 3435C > T and CYP2B6 516G > T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz

Mahungu, TW; Nair, D; Smith, CJ; Egan, D; Youle, M; Johnson, MA; Khoo, SH; ... Owen, A; + view all (2009) The Relationships of ABCB1 3435C > T and CYP2B6 516G > T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz. CLIN PHARMACOL THER , 86 (2) 204 - 211. 10.1038/clpt.2009.78.

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Abstract

Non-nucleoside reve rse transcriptase inhibitors (NNRTIs) are associated with a favorable increase in high-density lipoprotein cholesterol (HDL-c) level. Isolated studies have found a direct correlation between efavirenz (EFV) exposure and HDL-c level changes. Here we explore the impact that drug disposition variants associated with EFV exposure have on changes in HDL-c level. Seventy-six patients on first-line EFV-based regimens were genotyped for CYP2B6 516G>T and ABCB1 3435C>T. There was a 37% increase (+ 0.32 mmol/l, P 0.001) in mean HDL-c level over 48 weeks, and this was univariately associated with gender (male + 0.26 mmol/l, female + 0.55 mmol/l; P = 0.03), ABCB1 3435C>T (CC + 0.26 mmol/l, CT + 0.16 mmol/l, TT + 0.54 mmol/l; P-ANOVA = 0.003) and CYP2B6 516 G>T (GG + 0.27 mmol/l, GT + 0.29 mmol/l, TT + 0.72 mmol/l; P-ANOVA = 0.08). There was a significant association between the cumulative number of predictive genotypes (CYP2B6 516TT or ABCB1 3435TT) and mean HDL-c level change: (group 0 + 0.20 mmol/l, group 1 + 0.47 mmol/l, group 2 + 1.00 mmol/l; P-ANOVA < 0.0001). These findings need to be validated in independent cohorts.

Type: Article
Title: The Relationships of ABCB1 3435C > T and CYP2B6 516G > T With High-Density Lipoprotein Cholesterol in HIV-Infected Patients Receiving Efavirenz
DOI: 10.1038/clpt.2009.78
Keywords: REVERSE-TRANSCRIPTASE INHIBITORS, P-GLYCOPROTEIN EXPRESSION, ACQUIRED-IMMUNODEFICIENCY-SYNDROME, CORONARY-ARTERY DISEASE, HDL-CHOLESTEROL, HIV-1-INFECTED PATIENTS, INTRAINDIVIDUAL VARIABILITY, ANTIRETROVIRAL THERAPY, PLASMA-CONCENTRATIONS, PROTEASE INHIBITORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/138495
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